Generic Name: lurasidone (loo RAS i done)
Brand Names: Latuda
What is lurasidone?
Lurasidone is an antipsychotic medication. It works by changing the effects of chemicals in the brain.
Lurasidone is used to treat schizophrenia in adults.
Lurasidone may also be used for purposes not listed in this medication guide.
What is the most important information I should know about lurasidone?
Lurasidone is not for use in psychotic conditions related to dementia. Lurasidone may cause heart failure, sudden death, or pneumonia in older adults with dementia-related conditions. You should not use this medication if you are allergic to lurasidone, or if you are also using ketoconazole (Extina, Ketozole, Nizoral, Xolegal) or rifampin (Rifater, Rifadin, Rifamate).
Before you take lurasidone, tell your doctor if you have liver disease, kidney disease, heart disease, high blood pressure, heart rhythm problems, a history of heart attack or stroke, high cholesterol or triglycerides, low white blood cell (WBC) counts, seizures, diabetes, Parkinson's disease, trouble swallowing, or a history of breast cancer or suicidal thoughts.
While you are taking lurasidone, you may be more sensitive to temperature extremes such as very hot or cold conditions. Avoid getting too cold, or becoming overheated or dehydrated. Drink plenty of fluids, especially in hot weather and during exercise. It is easier to become dangerously overheated and dehydrated while you are taking lurasidone. Lurasidone may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert. Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Get up slowly and steady yourself to prevent a fall. Drinking alcohol can increase certain side effects of lurasidone. Stop using lurasidone and call your doctor at once if you have very stiff (rigid) muscles, high fever, sweating, confusion, fast or pounding heartbeats, feeling like you might pass out, tremors, or twitching or uncontrollable movements of your eyes, lips, tongue, face, arms, or legs.
There are many other drugs that can interact with lurasidone. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor. Keep a list of all your medicines and show it to any healthcare provider who treats you.
What should I discuss with my healthcare provider before taking lurasidone?
Lurasidone is not for use in psychotic conditions related to dementia. Lurasidone may cause heart failure, sudden death, or pneumonia in older adults with dementia-related conditions. You should not use this medication if you are allergic to lurasidone, or if you are also using ketoconazole (Extina, Ketozole, Nizoral, Xolegal) or rifampin (Rifater, Rifadin, Rifamate).
To make sure you can safely take lurasidone, tell your doctor if you have any of these other conditions:
- liver disease;
kidney disease;
heart disease, high blood pressure, heart rhythm problems;
a history of heart attack or stroke;
high cholesterol or triglycerides (a type of fat in the blood);
low white blood cell (WBC) counts;
a history of breast cancer;
seizures or epilepsy;
personal or family history of diabetes (lurasidone may raise your blood sugar);
a history of suicidal thoughts or actions;
Parkinson's disease; or
trouble swallowing.
Lurasidone may cause you to have high blood sugar (hyperglycemia). Talk to your doctor if you have any signs of hyperglycemia such as increased thirst or urination, excessive hunger, or weakness. If you are diabetic, check your blood sugar levels on a regular basis while you are taking lurasidone.
FDA pregnancy category B. Lurasidone is not expected to harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. It is not known whether lurasidone passes into breast milk or if it could harm a nursing baby. You should not breast-feed while using lurasidone.
Do not give this medication to a child without medical advice.
How should I take lurasidone?
Take exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.
Lurasidone should be taken with food (at least 350 calories).
Use lurasidone regularly to get the most benefit. Get your prescription refilled before you run out of medicine completely.
It may take several weeks before your symptoms improve. Keep using the medication as directed and tell your doctor if your symptoms do not improve. Store at room temperature away from moisture and heat.
See also: Lurasidone dosage (in more detail)
What happens if I miss a dose?
Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
Overdose symptoms may include some of the serious side effects listed in this medication guide.
What should I avoid while taking lurasidone?
While you are taking lurasidone, you may be more sensitive to temperature extremes such as very hot or cold conditions. Avoid getting too cold, or becoming overheated or dehydrated. Drink plenty of fluids, especially in hot weather and during exercise. It is easier to become dangerously overheated and dehydrated while you are taking lurasidone. Lurasidone may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.
Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Get up slowly and steady yourself to prevent a fall.
Drinking alcohol can increase certain side effects of lurasidone.
Lurasidone side effects
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop taking lurasidone and call your doctor at once if you have a serious side effect such as:
dizziness, fainting, fast or pounding heartbeats;
agitation, hostility, confusion, thoughts about hurting yourself;
seizure (convulsions);
fever, chills, body aches, flu symptoms, sores in your mouth and throat;
high blood sugar (increased thirst, increased urination, hunger, dry mouth, fruity breath odor, drowsiness, dry skin, blurred vision, weight loss);
very stiff (rigid) muscles, high fever, sweating, confusion, fast or uneven heartbeats, tremors, feeling like you might pass out;
trouble swallowing; or
twitching or uncontrollable movements of your eyes, lips, tongue, face, arms, or legs.
Less serious side effects may include:
drowsiness;
feeling restless;
nausea, diarrhea, stomach pain, loss of appetite;
blurred vision;
weight gain;
breast swelling or discharge;
missed menstrual periods; or
decreased sex drive, impotence, or difficulty having an orgasm.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Lurasidone Dosing Information
Usual Adult Dose for Schizophrenia:
40 mg orally once daily. Initial dose titration is not required. The maximum recommended dose is 80 mg once daily.
What other drugs will affect lurasidone?
Before you take lurasidone, tell your doctor if you regularly use other medicines that make you sleepy (such as cold or allergy medicine, narcotic pain medicine, sleeping pills, muscle relaxers, and medicine for seizures, depression, or anxiety). They can add to sleepiness caused by lurasidone.
Many drugs can interact with lurasidone. Below is just a partial list. Tell your doctor if you are using:
bosentan (Tracleer);
conivaptan (Vaprisol);
dexamethasone (Decadron, Hexadrol);
imatinib (Gleevec);
isoniazid (for treating tuberculosis);
St. John's wort;
an antibiotic such as clarithromycin (Biaxin), erythromycin (E.E.S., EryPed, Ery-Tab, Erythrocin), rifapentine (Priftin), or telithromycin (Ketek);
antifungal medication such as fluconazole (Diflucan), itraconazole (Sporanox), ketoconazole (Extina, Ketozole, Nizoral, Xolegal), or voriconazole (Vfend);
an antidepressant such as nefazodone;
heart or blood pressure medication such as diltiazem (Cartia, Cardizem), nicardipine (Cardene), quinidine (Quin-G), verapamil (Calan, Covera, Isoptin, Verelan), and others;
HIV/AIDS medicine such as atazanavir (Reyataz), delavirdine (Rescriptor), efavirenz (Sustiva, Atripla), etravirine (Intelence), fosamprenavir (Lexiva), indinavir (Crixivan), nelfinavir (Viracept), nevirapine (Viramune), saquinavir (Invirase), or ritonavir (Norvir, Kaletra);
medicines to treat narcolepsy, such as armodafanil (Nuvigil) or modafanil (Progivil); or
seizure medication such as carbamazepine (Carbatrol, Tegretol), felbamate (Felbatol), oxcarbazepine (Trileptal), phenobarbital (Solfoton), phenytoin (Dilantin), or primidone (Mysoline).
This list is not complete and other drugs may interact with lurasidone. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.
More lurasidone resources
- Lurasidone Side Effects (in more detail)
- Lurasidone Dosage
- Lurasidone Use in Pregnancy & Breastfeeding
- Lurasidone Drug Interactions
- Lurasidone Support Group
- 33 Reviews for Lurasidone - Add your own review/rating
- lurasidone Advanced Consumer (Micromedex) - Includes Dosage Information
- Lurasidone MedFacts Consumer Leaflet (Wolters Kluwer)
- Latuda Prescribing Information (FDA)
- Latuda Consumer Overview
- Latuda Monograph (AHFS DI)
Compare lurasidone with other medications
- Bipolar Disorder
- Borderline Personality Disorder
- Schizoaffective Disorder
- Schizophrenia
Where can I get more information?
- Your pharmacist can provide more information about lurasidone.
See also: lurasidone side effects (in more detail)
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